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TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells

2025-05-03

Abstract excerpt

TEA domain transcription factor 1 (TEAD1), a Hippo pathway transcription factor important in cellular homeostasis and development, is increasingly implicated in cancer biology. Here, we reveal a novel role for TEAD1 in organizing nuclear condensates, independent of active transcription. Using high-resolution imaging, ChIP-seq, RNA-seq and proximity-based proteomics, we demonstrate that in patient-derived renal cel...

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Literature Corpus work
ac07446f-57de-54d3-9576-38ade7f8b784
DOI
10.1101/2025.05.02.651992
Open publication

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TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cellsDOI 10.1101/2025.05.02.651992
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