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The structure of human CST reveals a decameric assembly bound to telomeric DNA

4 Jun 2020

Abstract excerpt

The CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and resolution of stalled replication forks genome-wide. Here, we report the 3.0-angstrom cryo-electron microscopy structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles as a decameric supercomplex. The atomic model of the 134-kilodalton CTC1 subunit, built almost entirely de novo, reveals the overall...

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PMID: 32499435
DOI: 10.1126/science.aaz9649

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