Article

DNA binding and bridging by human CtIP in the healthy and diseased states

2023-12-14

Abstract excerpt

The human DNA repair factor CtIP helps to initiate the resection of double-stranded DNA breaks for repair by homologous recombination, in part through its ability to bind and bridge DNA molecules. However, CtIP is a natively disordered protein that bears no apparent similarity to other DNA-binding proteins and so the structural basis for these activities remains unclear. In this work, we have used bulk DNA binding...

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Literature Corpus work: ede9ebe4-c151-5ab1-88a3-eb9e805d6c42
DOI: 10.1101/2023.12.14.571649

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