Article

Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

2022-01-24

Abstract excerpt

Human shelterin is a six-subunit complex – comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1 – that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains within shelterin, the architecture and stoichiometry of the full complex are currently unknown. Here we report th...

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Literature Corpus work: 70ccda3e-d72c-5410-8216-469face2f712
DOI: 10.1101/2022.01.24.477420

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