Article

The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA

2019-10-23

Abstract excerpt

The single-stranded DNA-binding CTC1-STN1-TEN1 (CST) complex is essential for telomere maintenance and genome-wide replication recovery, processes that are critical for genome stability. Here, we report the 2.95 Å cryo-EM structure of human CST bound to telomeric single-stranded DNA, which unexpectedly assembles as a decameric supercomplex. The atomic model of the 134 kDa CTC1, built almost entirely de novo , rev...

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Literature Corpus work: 6029e6ea-1135-5917-907c-c775112ff711
DOI: 10.1101/815886

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