Article
Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.
Protein science : a publication of the Protein Society - 1 Nov 2009
Khayrutdinov Bulat I, Bae Won Jin, Yun Young Mi, Lee Jie Hye, Tsuyama Takashi, Kim Jung Joo, Hwang Eunha, Ryu Kyoung-Seok, Cheong Hae-Kap, Cheong Chaejoon, Ko Jung-Soon, Enomoto Takemi, Karplus P Andrew, Güntert Peter, Tada Shusuke, Jeon Young Ho, Cho Yunje
Abstract excerpt
In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. The C-terminal domain of mouse Cdt1 (mCdt1C), the most conserved region in Cdt1, is essential for licensing and directly interacts with the MCM2-7 complex. We have determined the structures of mCdt1CS (mCdt1C_small; residues 452 to 557) and mCdt1CL (mCdt1C_large; residues 420 to 557) using...
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