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Article

Shelterin is a dimeric complex with extensive structural heterogeneity

26 Jul 2022

Abstract excerpt

Human shelterin is a six-subunit complex-composed of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1-that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains within shelterin, the architecture and stoichiometry of the full complex are currently unknown. Here, we report the...

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Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 35881804
DOI: 10.1073/pnas.2201662119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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