Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.

Cell cycle (Georgetown, Tex.) - 2 May 2016

You Zhiying, Ode Koji L, Shindo Mayumi, Takisawa Haruhiko, Masai Hisao

Abstract excerpt

All organisms ensure once and only once replication during S phase through a process called replication licensing. Cdt1 is a key component and crucial loading factor of Mcm complex, which is a central component for the eukaryotic replicative helicase. In higher eukaryotes, timely inhibition of Cdt1 by Geminin is essential to prevent rereplication. Here, we address the mechanism of DNA licensing using purified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to DNA Replication

Share to Minichromosome Maintenance Proteins

Share to Mutant Proteins

Share to Xenopus laevis

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26940553
DOI: 10.1080/15384101.2015.1106652
PMCID: PMC4889252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.PMID 26940553Read ↗

Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication.Semantic proximity Read ↗

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.Semantic proximity Read ↗

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read ↗

Mutant analysis of Cdt1's function in suppressing nascent strand elongation during DNA replication in Xenopus egg extracts.Semantic proximity Read ↗

Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.Semantic proximity Read ↗

A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing.Semantic proximity Read ↗

Cdt1 variants reveal unanticipated aspects of interactions with Cyclin/CDK and MCM important for normal genome replicationSemantic proximity Read ↗

Distinct and sequential re-replication barriers ensure precise genome duplicationSemantic proximity Read ↗

Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.Semantic proximity Read ↗

Cdt1 Phosphorylation by Cyclin A-dependent Kinases Negatively Regulates Its Function without Affecting Geminin BindingSemantic proximity Read ↗

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.Semantic proximity Read ↗

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.