Article
DNA binding and bridging by human CtIP in the healthy and diseased states.
Nucleic acids research - 12 Aug 2024
Lokanathan Balaji Shreya, De Bragança Sara, Balaguer-Pérez Francisco, Northall Sarah, Wilkinson Oliver John, Aicart-Ramos Clara, Seetaloo Neeleema, Sobott Frank, Moreno-Herrero Fernando, Dillingham Mark Simon
Abstract excerpt
The human DNA repair factor CtIP helps to initiate the resection of double-stranded DNA breaks for repair by homologous recombination, in part through its ability to bind and bridge DNA molecules. However, CtIP is a natively disordered protein that bears no apparent similarity to other DNA-binding proteins and so the structural basis for these activities remains unclear. In this work, we have used bulk DNA...
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