Article
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2009
De Marco V, Gillespie P J, Li A, Karantzelis N, Christodoulou E, Klompmaker R, van Gerwen S, Fish A, Petoukhov M V, Iliou M S, Lygerou Z, Medema R H, Blow J J, Svergun D I, Taraviras S, Perrakis A
Abstract excerpt
All organisms need to ensure that no DNA segments are rereplicated in a single cell cycle. Eukaryotes achieve this through a process called origin licensing, which involves tight spatiotemporal control of the assembly of prereplicative complexes (pre-RCs) onto chromatin. Cdt1 is a key component a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.