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Article

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

The Journal of biological chemistry - 21 Sept 2012

Soares Dinesh C, Bradshaw Nicholas J, Zou Juan, Kennaway Christopher K, Hamilton Russell S, Chen Zhuo A, Wear Martin A, Blackburn Elizabeth A, Bramham Janice, Böttcher Bettina, Millar J Kirsty, Barlow Paul N, Walkinshaw Malcolm D, Rappsilber Juri, Porteous David J

Abstract excerpt

Paralogs NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment. Both proteins are predicted to have similar structures, based upon high sequence similarity, and they co-complex in mammalian cells. X-ray diffraction studies and homology modelin...

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Identifiers

PMID: 22843697
DOI: 10.1074/jbc.M112.393439
PMCID: PMC3463352

Genes

NDE1
NDEL1
DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22843697-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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