Article

<i>APOE</i> deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

2022-06-30

Abstract excerpt

The apolipoprotein E ( APOE ) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain transporting lipids such as cholesterol among different brain cell types. Here, we show that APOE deficiency in human iPSC-derived cerebral organoids impacts brain lipid homeostasis by modulating mult...

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Literature Corpus work: de94d718-4953-501f-9399-638ac50070f7
DOI: 10.1101/2022.06.30.498241

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