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Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategies

2024-04-05

Abstract excerpt

<h4>SUMMARY</h4> The blood-brain barrier (BBB), formed by specialized brain microvascular endothelial cells (BMECs), regulates brain function in health and disease. In vitro modeling of the human BBB is limited by the lack of robust hiPSC protocols to generate BMECs. Here, we report generation, transcriptomic and functional characterization of reprogrammed BMECs (rBMECs) by combining hiPSC differentiation into B...

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Literature Corpus work
6fbc6f7c-dc8f-5c3e-8843-757d0c53d9ea
DOI
10.1101/2024.04.03.588012
Open publication

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Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategiesDOI 10.1101/2024.04.03.588012
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