Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

18 Jul 2019

Abstract excerpt

OBJECTIVE: The ApoE (apolipoprotein) allele epsilon 4 is a major genetic risk factor for Alzheimer disease, cardiovascular disorders, and stroke, indicating that it significantly impacts cerebral and vascular systems. However, very little is known about how APOE genotype affects brain endothelial cells, which form a network of tight junctions to regulate communication between the brain and circulating blood...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Barrier Structure and Function Studies
Share to Clusterin in disease pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31315437
DOI: 10.1161/atvbaha.118.312261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial CellsPMID 31315437Read ↗

APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A ActivationSemantic proximity Read ↗

ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cellsSemantic proximity Read ↗

iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid betaSemantic proximity Read ↗

APOE genotype confers context dependent neurovascular vulnerability in immune-vascularized human forebrain organoidsSemantic proximity Read ↗

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Semantic proximity Read ↗

The role of APOE in cerebrovascular dysfunction.Semantic proximity Read ↗

Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype.Semantic proximity Read ↗

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseasesSemantic proximity Read ↗

Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles.Semantic proximity Read ↗

Cholesterol and matrisome pathways dysregulated in human <i>APOE</i> ε4 gliaSemantic proximity Read ↗

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.