Vascular-Perfusable Human 3D Brain-on-Chip

Abstract excerpt

Development and delivery of treatments for neurological diseases are limited by the tight and selective human blood–brain barrier (BBB). Although animal models have been important research and preclinical tools, the rodent BBB exhibits species differences and fails to capture the complexity of human genetics. Microphysiological systems incorporating human-derived cells hold great potential for modeling disease and...

Topics

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• 3D Printing in Biomedical Research
• Barrier Structure and Function Studies
• Blood-Brain Barrier
• Cell Culture Techniques
• Endothelial Cells
• Extracellular Matrix
• Models, Cardiovascular
• Neovascularization, Pathologic

Identifiers and source

Literature Corpus work

2ff6c4b8-0c6a-54cd-b0dd-a7fe5067cc6d

DOI

10.1101/2025.09.18.676925