Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Abstract excerpt

<title>Abstract</title> <p>Patient-specific, human-based cellular models integrating a biomimetic blood-brain barrier (BBB), immune, and myelinated neuron components are critically needed to enable accelerated, translationally relevant discovery of neurological disease mechanisms and interventions. By engineering a novel brain-mimicking 3D hydrogel and co-culturing all six major brain cell types derived from pati...

Topics

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• 3D Printing in Biomedical Research
• Glioma Diagnosis and Treatment
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

586f282a-a9c4-5825-b9fe-b330e0649de4

DOI

10.21203/rs.3.rs-4577378/v1