Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human telomeres replicate using chromosome-specific, rather than universal, replication programs

16 Apr 2012

Abstract excerpt

Telomeric and adjacent subtelomeric heterochromatin pose significant challenges to the DNA replication machinery. Little is known about how replication progresses through these regions in human cells. Using single molecule analysis of replicated DNA (SMARD), we delineate the replication programs-i.e., origin distribution, termination site location, and fork rate and direction-of specific telomeres/subtelomeres of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22508510
DOI: 10.1083/jcb.201112083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human telomeres replicate using chromosome-specific, rather than universal, replication programsPMID 22508510Read ↗

Telomere-to-telomere human DNA replication timing profilesSemantic proximity Read ↗

Delayed DNA replication in haploid human embryonic stem cellsSemantic proximity Read ↗

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read ↗

Allele-specific analysis of DNA replication origins in mammalian cells.Semantic proximity Read ↗

Spatiotemporal regulation of DNA replication in the human genome and its association with genomic instability and disease.Semantic proximity Read ↗

Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA SequencesSemantic proximity Read ↗

TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere DysfunctionSemantic proximity Read ↗

The Genomic Architecture of Human DNA Replication OriginsSemantic proximity Read ↗

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read ↗

Cohesin-mediated loop anchors confine the location of human replication originsSemantic proximity Read ↗

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear LocalizationSemantic proximity Read ↗

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.