Article

Repli-seq: genome-wide analysis of replication timing by next-generation sequencing

2017-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Cycling cells duplicate their DNA content during S phase, following a defined program called replication timing (RT). Early and late replicating regions differ in terms of mutation rates, transcriptional activity, chromatin marks and sub-nuclear position. Moreover, RT is regulated during development and is altered in disease. Exploring mechanisms linking RT to other cellular processes in normal...

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Literature Corpus work: dd4d75fe-53f4-5c12-b5d7-83d215095cd7
DOI: 10.1101/104653

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