Article
Replication timing and transcriptional control: beyond cause and effect.
Current opinion in cell biology - 1 Jun 2002
Gilbert David M
Abstract excerpt
In general, transcriptionally active euchromatin replicates during the first half of S phase, whereas silent heterochromatin replicates during the second half. Moreover, changes in replication timing accompany key stages of development. Although there is not a strict correlation between replication timing and transcription per se, recent results reveal a strong relationship between heritably repressed chromatin...
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