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ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication origins

2023-03-07

Abstract excerpt

Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains unclear. We show that the ORC1 subunit of the human Origin Recognition Complex interacts with RNAs transcribed from genes with origins in their transcription start sites (TSSs),...

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Identifiers and source

Literature Corpus work
4f549f8a-9569-5cb3-b31a-96938f717a21
DOI
10.1101/2023.03.07.531515
Open publication

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ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication originsDOI 10.1101/2023.03.07.531515
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