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Article

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress.

Nature communications - 10 Feb 2020

Chong Shin Yen, Cutler Sam, Lin Jing-Jer, Tsai Cheng-Hung, Tsai Huai-Kuang, Biggins Sue, Tsukiyama Toshio, Lo Yi-Chen, Kao Cheng-Fu

Abstract excerpt

Transcription-replication conflicts (TRCs) occur when intensive transcriptional activity compromises replication fork stability, potentially leading to gene mutations. Transcription-deposited H3K4 methylation (H3K4me) is associated with regions that are susceptible to TRCs; however, the interplay between H3K4me and TRCs is unknown. Here we show that H3K4me aggravates TRC-induced replication failure in...

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Identifiers

PMID: 32041946
DOI: 10.1038/s41467-020-14595-4
PMCID: PMC7010754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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