Article

Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humans

2019-08-16

Abstract excerpt

The spatio-temporal program of genome replication across eukaryotes is thought to be driven both by the uneven loading of pre-replication complexes (pre-RCs) across the genome at the onset of S-phase, and by differences in the timing of activation of these complexes during S-phase. To determine the degree to which distribution of pre-RC loading alone could account for chromosomal replication patterns, we mapped th...

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Literature Corpus work: 787c23f7-e3b8-5680-a964-285ea13ffe72
DOI: 10.1101/737742

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