Article

FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNA

2026-03-26

Abstract excerpt

<h4>SUMMARY</h4> The FET family of RNA-binding proteins, FUS, EWSR1, and TAF15, contribute to transcriptional regulation and RNA maturation, but their core functions remain unclear. Chromosomal rearrangements involving FUS, EWSR1, or TAF15 drive multiple cancers, and mutations in the genes encoding the FET proteins are associated with neurodegenerative disease. Here, using nanoscale imaging, we show that endogeno...

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Literature Corpus work: 3a27e7bb-0a3e-570f-990f-1e1fa7895592
DOI: 10.64898/2026.03.24.713985

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