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Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications

6 Jan 2023

Abstract excerpt

Ewing sarcoma is the second most common bone tumor in childhood and adolescence. Currently, first-line therapy includes multidrug chemotherapy with surgery and/or radiation. Although most patients initially respond to chemotherapy, recurrent tumors become treatment refractory. Pathologically, Ewing sarcoma consists of small round basophilic cells with prominent nuclei marked by expression of surface protein CD99....

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PMID: 36672331
DOI: 10.3390/cancers15020382

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