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Article

Ewing Sarcoma Protein: A Key Player in Human Cancer

1 Jan 2013

Abstract excerpt

The Ewing sarcoma protein (EWS) is a well-known player in cancer biology for the specific translocations occurring in sarcomas. The EWS-FLI1 gene fusion is the prototypical translocation that encodes the aberrant, chimeric transcription factor, which is a landmark of Ewing tumors. In all described Ewing sarcoma oncogenes, the EWS RNA binding domains are completely missing; thus RNA binding properties are not...

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PMID: 24082883
DOI: 10.1155/2013/642853

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