ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3

Abstract excerpt

The mechanistic basis for the metastasis of Ewing sarcomas remains poorly understood, as these tumors harbor few mutations beyond the chromosomal translocation that initiates the disease. Instead, the epigenome of Ewing sarcoma (EWS) cells reflects the regulatory state of genes associated with the DNA binding activity of the fusion oncoproteins EWSR1::FLI1 or EWSR1::ERG. In this study, we examined the EWSR1::FLI1/...

Topics

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• CAR-T cell therapy research
• Genomics and Chromatin Dynamics
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• RNA Research and Splicing
• Sarcoma Diagnosis and Treatment
• Ubiquitin and proteasome pathways
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

4ada6dde-8a81-5486-b47a-3b49922d7bd5

DOI

10.1101/2023.12.21.572864