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Article

FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex

8 Apr 2019

Abstract excerpt

Members of the human FET family of RNA-binding proteins, comprising FUS, EWSR1, and TAF15, are ubiquitously expressed and engage at several levels of gene regulation. Many sarcomas and leukemias are characterized by the expression of fusion oncogenes with FET genes as 5' partners and alternative transcription factor-coding genes as 3' partners. Here, we report that the N terminus of normal FET proteins and their...

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PMID: 30962207
DOI: 10.15252/embr.201845766

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