Article

Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma

2019-10-16

Abstract excerpt

<h4>SUMMARY</h4> Ewing sarcoma (EwS) is an aggressive childhood malignancy with a high propensity for metastasis. By analyzing cohorts of patients and age-matched healthy donors, we establish that EwS metastatic progression is accompanied by elevated plasma levels of multiple proinflammatory cytokines, interferons and extracellular vesicles (EVs). The latter were enriched with transcripts derived from LINE, SINE...

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Literature Corpus work: be3f4ddb-4be2-5bd3-b499-ed7cdcdbd02a
DOI: 10.1101/806851

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