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Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

2021-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Cell lines have been essential for major discoveries in cancer including Ewing sarcoma (EwS). EwS is a highly aggressive pediatric bone or soft-tissue cancer characterized by oncogenic EWSR1-ETS fusion transcription factors converting polymorphic GGAA-microsatellites (mSats) into neo-enhancers. However, further detailed mechanistic evaluation of gene regulation in EwS have been hindered by the l...

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Literature Corpus work
55ba7bbc-e9da-5e32-8768-396f4161b53e
DOI
10.1101/2021.06.08.447518
Open publication

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Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationDOI 10.1101/2021.06.08.447518
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