Article

<i>LINC00205</i> acts as a multivalent scaffold promoting FUS <sup>P525L</sup> recruitment in Amyotrophic Lateral Sclerosis stress granules

2026-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Stress granules (SG) are dynamic, membrane-less ribonucleoprotein assemblies that orchestrate cellular stress responses and rapidly disassemble upon stress relief. In Amyotrophic Lateral Sclerosis (ALS), mutations in RNA-binding proteins such as Fused in Sarcoma (FUS) impair SG dynamics, promoting the formation of aberrant and persistent granules. Although long non-coding RNAs (lncRNAs) are emer...

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Literature Corpus work: f3a44585-7431-596c-883b-644f0b54c03f
DOI: 10.64898/2026.04.08.715854

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