Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic Opportunities

5 Jun 2022

Abstract excerpt

Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 reprograms the epigenetic state, alters gene expression, and thus leads to tumorigenesis. Considerable studies have investigated the epigenomic and transcriptomic profiling of EwS. Nevertheless, a comprehensive view of therapeutic targets is still...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Peptidase Inhibition and Analysis
Share to Protein Degradation and Inhibitors
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35740349
DOI: 10.3390/biomedicines10061325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic OpportunitiesPMID 35740349Read ↗

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational ModificationsSemantic proximity Read ↗

Ewing sarcoma fusion oncogene: At the crossroads of transcription and DNA damage responseSemantic proximity Read ↗

Ewing Sarcoma Protein: A Key Player in Human CancerSemantic proximity Read ↗

ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3Semantic proximity Read ↗

Molecular Changes Associated With Tumor Initiation and Progression of Soft Tissue Sarcomas: Targeting the Genome and Epigenome.Semantic proximity Read ↗

Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic LandscapesSemantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity Read ↗

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcomaSemantic proximity Read ↗

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcomaSemantic proximity Read ↗

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.