Article

Multidirectional Cellular Plasticity in Ewing Sarcoma Reveals a Tumor–CAF Continuum and Novel Immunotherapeutic Targets

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EwS) is an aggressive pediatric malignancy with poor outcomes for patients with metastatic or relapsed disease. Effective immunotherapeutic approaches, including CAR T-cell therapy, are limited by intratumoral heterogeneity, an incompletely characterized tumor microenvironment (TME), and a lack of well-defined, tumor-restricted target antigens. To address these limitations, we per...

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Literature Corpus work: 291fec8f-2010-543e-9045-89acb56e71aa
DOI: 10.64898/2026.08.03.742600

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