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DNA supercoiling links transcription and chromatin architecture during human stem cell differentiation

2026-02-12

Abstract excerpt

Transcription imposes torsional stress on chromatin, leading to over– or under-winding of the DNA helix. Yet, how supercoiling evolves during dynamic changes in gene expression, and how it influences three-dimensional chromatin contacts in the densely packed human genome, remains unclear. Here, we map genome-wide negative supercoiling and chromatin interactions at high resolution in human embryonic stem cells, usi...

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Literature Corpus work
3849dca9-6a88-5850-9f1a-ab302b7cb7c7
DOI
10.64898/2026.02.12.705511
Open publication

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DNA supercoiling links transcription and chromatin architecture during human stem cell differentiationDOI 10.64898/2026.02.12.705511
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