Article

CpG islands act as topological sinks for transcription-induced DNA supercoiling

2026-08-25

Abstract excerpt

Strong evolutionary selection has maintained CpG-dense islands (CGIs) at the promoters of constitutively expressed genes throughout the vertebrate genome, suggesting an important role in regulating DNA topology. Here, using Twist-seq, a psoralen-based approach for quantitative genome-wide profiling of DNA supercoiling, we reveal distinct topological states across human gene promoters. We show that CGI promoters ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c48ff3f-de56-5e01-8a25-cacaa2abcf6e
DOI: 10.64898/2026.08.24.746546

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CpG islands act as topological sinks for transcription-induced DNA supercoilingDOI 10.64898/2026.08.24.746546Read

Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedbackSemantic proximity Read

DNA supercoiling links transcription and chromatin architecture during human stem cell differentiationSemantic proximity Read

Hierarchical prediction and perturbation of chromatin organization reveal how loop domains mediate higher-order architecturesSemantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

GPSeq reveals the radial organization of chromatin in the cell nucleusSemantic proximity Read

Human Smc5/6 recognises transcription-generated positive DNA supercoilsSemantic proximity Read

DNA Mechanical Strain Steers Transcription Factor RecognitionSemantic proximity Read

Control of RNA polymerase II promoter-proximal pausing by DNA supercoilingSemantic proximity Read

Intrinsic DNA codes govern distinct modes of nucleosome-transcription factor interactionsSemantic proximity Read

Assessing base-resolution DNA mechanics on the genome scaleSemantic proximity Read

Human Smc5/6 recognises transcription-generated positive DNA supercoilsSemantic proximity Read

Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of MagnitudeSemantic proximity Read