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Human Smc5/6 recognises transcription-generated positive DNA supercoils

2023-05-04

Abstract excerpt

<h4>Summary</h4> Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which is lost upon chromosomal DNA integration. How the complex distinguishes among different DNA templates is unknown. Here we show that, in human cells, Smc5/6 p...

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Literature Corpus work
c449e6ec-abcf-5367-b202-8d24ee183d32
DOI
10.1101/2023.05.04.539344
Open publication

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Human Smc5/6 recognises transcription-generated positive DNA supercoilsDOI 10.1101/2023.05.04.539344
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