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Human Smc5/6 recognises transcription-generated positive DNA supercoils

6 Sept 2024

Abstract excerpt

Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to and impedes the transcription of extrachromosomal DNA templates; an ability which is lost upon integration of the DNA into the chromosome. How the complex distinguishes among different DNA templates is unknown. Here we show that, in human cells, Smc5/6...

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PMID: 39242537
DOI: 10.1038/s41467-024-50646-w

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