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Article

Chromatin architecture reorganization during stem cell differentiation.

Nature - 19 Feb 2015

Dixon Jesse R, Jung Inkyung, Selvaraj Siddarth, Shen Yin, Antosiewicz-Bourget Jessica E, Lee Ah Young, Ye Zhen, Kim Audrey, Rajagopal Nisha, Xie Wei, Diao Yarui, Liang Jing, Zhao Huimin, Lobanenkov Victor V, Ecker Joseph R, Thomson James A, Ren Bing

Abstract excerpt

Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage specification remains to be determined. By mapping genome-wide chromatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25693564
DOI: 10.1038/nature14222
PMCID: PMC4515363

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