Article

Gene syntax defines supercoiling-mediated transcriptional feedback

2025-01-19

Abstract excerpt

Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus profoundly impacts the transcription of nearby adjacent genes, but the molecular basis of this effect remains poorly understood. Here, using integrated reporter circuits in human cells, we show that the reciprocal effects of transcripti...

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Identifiers and source

Literature Corpus work: 9f844677-9264-5831-85b3-1f7ead624716
DOI: 10.1101/2025.01.19.633652

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