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Article

Negative supercoil at gene boundaries modulates gene topology.

Nature - 1 Jan 2020

Achar Yathish Jagadheesh, Adhil Mohamood, Choudhary Ramveer, Gilbert Nick, Foiani Marco

Abstract excerpt

Transcription challenges the integrity of replicating chromosomes by generating topological stress and conflicts with forks1,2. The DNA topoisomerases Top1 and Top2 and the HMGB family protein Hmo1 assist DNA replication and transcription3-6. Here we describe the topological architecture of genes in Saccharomyces cerevisiae during the G1 and S phases of the cell cycle. We found under-wound DNA at gene boundaries...

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Source

Identifiers

PMID: 31969709
DOI: 10.1038/s41586-020-1934-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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