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Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of <i>MAPT</i> Mutation iPSC-derived Neurons

2024-06-01

Abstract excerpt

Tau protein aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP), spurring development of tau-lowering therapeutic strategies. Here, we report fully human bifunctional anti-tau-PEST intrabodies that bind the mid-domain of tau to block aggregation and degrade tau via the proteasome using the ornithine d...

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Literature Corpus work: 38135587-413c-55a0-9281-a8d4265d8688
DOI: 10.1101/2024.05.28.596248

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Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of <i>MAPT</i> Mutation iPSC-derived NeuronsDOI 10.1101/2024.05.28.596248Read

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