Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.

Science advances - 31 Jul 2026

Tsefou Eliona, Bez Sumi, Birkle Timothy J Y, Foiani Martha, Watamura Naoto, Bourdenx Mathieu, Gavriouchkina Daria, Turkes Emir, Crawford Samuel, Coneys Rachel, Isaacs Adrian M, Duff Karen E

Abstract excerpt

The accumulation of pathological four-repeat (4R) tau is central to several frontotemporal dementia (FTD) subtypes, but human neuronal models amenable to high-throughput screening of 4R tau-targeting therapies remain very limited. To address this, we developed induced pluripotent stem cell (iPSC)-derived i3Neuron (i3N) lines expressing >75% 4R tau, driven by FTD splice-shifting mutations (Ser305Asn; S305N or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MAPT gene
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neurons

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 42536730
DOI: 10.1126/sciadv.aeg1445
PMCID: PMC13426404

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.PMID 42536730Read ↗

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tauSemantic proximity Read ↗

A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology.Semantic proximity Read ↗

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilitySemantic proximity Read ↗

Human iPSC 4R tauopathy model uncovers modifiers of tau propagationSemantic proximity Read ↗

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read ↗

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes.Semantic proximity Read ↗

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic functionSemantic proximity Read ↗

Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of <i>MAPT</i> Mutation iPSC-derived NeuronsSemantic proximity Read ↗

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.Semantic proximity Read ↗

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.Semantic proximity Read ↗

Tau depletion in human neurons mitigates Aβ-driven toxicitySemantic proximity Read ↗

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau PathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.