Article

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death

2021-04-26

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Tau post-translational modifications (PTMs) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD). Tau proteolysis by caspases, including caspase-6, represents an understudied PTM that may increase neurotoxicity and tau self-aggregation. <bol...

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Literature Corpus work: e94889a3-4151-5605-ab79-b5fc68038cc7
DOI: 10.21203/rs.3.rs-300172/v2

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