Article

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

2025-07-15

Abstract excerpt

The accumulation of pathological four-repeat (4R) tau is central to several frontotemporal dementia (FTD) subtypes, but human neuronal models amenable to high-throughput screening of 4R tau-targeting therapies remain very limited. To address this, we developed iPSC-derived i 3 Neuron (i 3 N) lines expressing >75% 4R tau, driven by FTD splice-shifting mutations (S305N or S305N/IVS10+3). These neurons develop hype...

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Literature Corpus work: 9837a442-6ad4-5545-9c81-e26515fbce1a
DOI: 10.1101/2025.07.11.664346

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