Article

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunction

2022-11-21

Abstract excerpt

<title>Abstract</title> The microtubule-associated protein TAU is a key driver of the neurodegeneration observed in Alzheimer’s disease (AD). Normally, TAU stabilizes neuronal microtubules (MT) and promotes essential MT-associated functions. Alternative splicing of the TAU-encoding <italic>MAPT</italic> gene results in the expression of six isoforms in the human brain. Models of AD and TAU pathology to date ar...

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Literature Corpus work: abccc19a-72f3-5b78-89aa-fa021961319e
DOI: 10.21203/rs.3.rs-2277268/v1

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