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Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Stem cell reports - 13 Sept 2016

Silva M Catarina, Cheng Chialin, Mair Waltraud, Almeida Sandra, Fong Helen, Biswas M Helal U, Zhang Zhijun, Huang Yadong, Temple Sally, Coppola Giovanni, Geschwind Daniel H, Karydas Anna, Miller Bruce L, Kosik Kenneth S, Gao Fen-Biao, Steen Judith A, Haggarty Stephen J

Abstract excerpt

Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. However, the mechanism of neuronal loss is not fully understood. To identify molecular events associated with tauopathy, we studied induced pluripotent stem cell (iPSC)-derived neurons from individuals carrying the tau-A152T...

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Identifiers

PMID: 27594585
DOI: 10.1016/j.stemcr.2016.08.001
PMCID: PMC5032560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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