Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology.

Science translational medicine - 8 Apr 2026

Dannert Angelika, Schulz Nathalie, Klimmt Julien, Knez Lea, Groschup Bernhard, Gonçalves Carolina Cardoso, Carraro Caterina, Schifferer Martina, Brendel Matthias, Paquet Dominik

Abstract excerpt

Tauopathies, such as Alzheimer's disease and frontotemporal dementia, are common neurodegenerative diseases characterized by misfolding, hyperphosphorylation, and aggregation of tau. Molecular mechanisms underlying tauopathies are still poorly understood, which is in part due to a lack of human models autonomously developing major disease hallmarks. The formation of late-stage disease phenotypes may require adult...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Neurons

Share to Phosphorylation

Share to Protein Isoforms

Share to tau Proteins

Share to Tauopathies

Source

Identifiers

PMID: 41950304
DOI: 10.1126/scitranslmed.adu9845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology.PMID 41950304Read ↗

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerabilitySemantic proximity Read ↗

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tauSemantic proximity Read ↗

Human iPSC 4R tauopathy model uncovers modifiers of tau propagationSemantic proximity Read ↗

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.Semantic proximity Read ↗

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read ↗

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes.Semantic proximity Read ↗

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.Semantic proximity Read ↗

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic functionSemantic proximity Read ↗

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read ↗

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau PathologySemantic proximity Read ↗

Tau depletion in human neurons mitigates Aβ-driven toxicitySemantic proximity Read ↗

Embryonic Stem Cell–Based Modeling of Tau Pathology in Human NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.