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A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

2025-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly sampled across a diverse set of brain regions and neurodegenerative and neuroinflammatory diseases obtained from 161 donors sampled at autopsy or during a neurosurgical procedure. Using single-cell hier...

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Literature Corpus work
a4e0aa68-a327-5a6f-84f0-9454daede8a5
DOI
10.1101/2025.03.27.641500
Open publication

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A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signatureDOI 10.1101/2025.03.27.641500
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