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Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s Disease

2023-10-26

Abstract excerpt

The complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer’s disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human myeloid cells from the prefrontal cortex of 1,607 unique donors covering the human lifespan and varying degrees of AD neuropathology. We delineated 13 transcriptionally distinct myeloid subtypes or...

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Literature Corpus work
45d21e6d-7664-5668-92be-9c16ed629457
DOI
10.1101/2023.10.25.23297558
Open publication

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Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer’s DiseaseDOI 10.1101/2023.10.25.23297558
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