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Novel Master Regulators of Microglial Phagocytosis and Repurposed FDA-approved Drug for Treatment of Alzheimer Disease

2022-10-21

Abstract excerpt

<h4>Summary</h4> Microglia, the innate immune cells of the brain, are essential determinants of late-onset Alzheimer’s Disease (LOAD) neuropathology. Here, we developed an integrative computational systems biology approach to construct causal network models of genetic regulatory programs for microglia in Alzheimer’s Disease (AD). This model enabled us to identify novel key driver (KDs) genes for microglial functi...

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Literature Corpus work
8d225e18-2267-5fcb-aed2-b1e3aa1aa57a
DOI
10.1101/2022.10.19.512953
Open publication

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Novel Master Regulators of Microglial Phagocytosis and Repurposed FDA-approved Drug for Treatment of Alzheimer DiseaseDOI 10.1101/2022.10.19.512953
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