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Article

Network dynamics-based subtyping of Alzheimer's disease with microglial genetic risk factors.

Alzheimer's research & therapy - 16 Oct 2024

Choi Jae Hyuk, Lee Jonghoon, Kang Uiryong, Chang Hongjun, Cho Kwang-Hyun

Abstract excerpt

BACKGROUND: The potential of microglia as a target for Alzheimer's disease (AD) treatment is promising, yet the clinical and pathological diversity within microglia, driven by genetic factors, poses a significant challenge. Subtyping AD is imperative to enable precise and effective treatment strategies. However, existing subtyping methods fail to comprehensively address the intricate complexities of AD...

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Identifiers

PMID: 39415193
DOI: 10.1186/s13195-024-01583-9
PMCID: PMC11481771

Genes

CASS4
INPP5D
LAT2
PICALM
SPI1

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